This book is a collection of invited contributions from speakers at the 50th Annual Symposium of the Society of General Physiologists on Cytoskeletal Regulation of Membrane Function. A theme that connected the diverse speakers was a fascination with the molecular interactions at the interface between the plasma membrane and cytoplasm of metazoan cells. This research area was once primarily of interest to biochemists and basic cell biologists, but, as exemplified at this meeting, is of importance to physiologists, neuroscientists, and clinicians as well.